Breast cancer gene mutations may also
lead to heart problems
The Globe and Mail
Dr. Subodh Verma's research team have discovered evidence that a genetic mutation linked to higher rates of breast cancer may also play a critical role in regulating proper heart function.
Also appeared on: The
Winnipeg Free Press,
St. Michael's and King Saud Receive First Joint Patent
St. Michael’s Hospital and
Dr. Subodh Verma, a cardiac surgeon at St.
Michael’s, and Dr. Mohammed Al-Omran, a vascular surgeon at the largest
Obtaining the patent is an initial step in
realizing the potential of this innovative approach to treating one of
the leading causes of death in
Dr. Verma’s team published three papers in 2011, in Nature Communications, the Journal of Biological Chemistry and Gene Therapy, showing how the BRCA1 and 2 genes, which normally suppresses the growth of breast and ovarian tumours, also protect the heart.
Following a heart attack, mice with the
mutated BRCA1 gene had a three-to-five times higher rate of death. This
was largely due to the development of profound heart failure and poor
Dr. Verma said the mutated BRCA1 gene may
“The patent is also significant because it
demonstrates how collaborative research between St. Michael’s and
Vivien Thomas Young Investigator Award
We are very pleased to announce that Krishna Kumar Singh, PhD from Dr Subodh Verma's research laboratory at St Michael's Hospital, has received the prestigious 2009 Vivien Thomas Young Investigator Award from the American Heart Association for their work elucidating the role of the tumour suppressor gene BRCA1 as a regulator of endothelial dysfunction and atherosclerosis.