Yi Pan
Research Technician
MD
416-864-6060/x77624
pany@smh.ca
Research interests are focused on exploring importance of visfatin on endothelial cell function. Visfatin, an adipokine recently identified in the visceral fat of humans, corresponds to pre-B cell colony-enhancing factor (PBEF). PBEF was proposed to be a cytokine that stimulates the maturation of pre-B-cells in the presence of IL-7 and stem cell factor. Visfatin exerted insulin-mimetic effects via binding and activation of the insulin receptor in cultured adipocytes, hepatocytes and myocytes cells and lowered plasma glucose levels in mice. Furthermore, it has been demonstrated that visfatin possesses nicotinamide phosphoribosyltransferase (Nampt) activity which is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) biosynthesis. This activity was shown to be important for vascular smooth muscle cell maturation, indicating its possible involvement in vascular pathology. Despite the growing availability of visfatin/PBEF/Nampt data in the literature, little is known about visfatin/PBEF/Nampt in endothelium cells. In our studies we will evaluate the role of visfatin/PBEF/Nampt on the endothelial function
Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S.
BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure.
J Biol Chem. 2012 Feb 24;287(9):6604-14
Yanagawa B, Lovren F, Pan Y, Garg V, Quan A, Tang G, Singh KK, Shukla PC, Kalra NP, Peterson MD, Verma S.
miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis.
J Thorac Cardiovasc Surg. 2012 Feb 13.
Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, Leong-Poi H, Al-Omran M, Verma S.
BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis.
Gene Ther. 2012 Jan 19. doi: 10.1038/gt.2011.214.
Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S.
BRCA1 is an essential regulator of heart function and survival following myocardial infarction.
Nat Commun. 2011 Dec 20;2:593.
Singh KK, Shukla PC, Quan A, Lovren F, Pan Y, Wolfstadt JI, Gupta M, Al-Omran M, Leong-Poi H, Teoh H, Verma S.
Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death.
Biochem Biophys Res Commun. 2011 Jul 29;411(2):421-6.
Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, Al-Omran M, Teoh H, Verma S.
Adropin is a novel regulator of endothelial function
Circulation. 2010 Sep 14;122(11 Suppl):S185-92.
Lovren F, Pan Y, Quan A, Szmitko PE, Singh KK, Shukla PC, Gupta M, Chan L, Al-Omran M, Teoh H, Verma S.
Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages.
Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H656-63.
Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M, Verma S.
Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis.
Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1440-9.
Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S.
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1377-84.