VERMALAB

 

CARDIOMETABOLIC RESEARCH



Krishna Kumar Singh


 Research Associate
 PhD
 416-864-6060 x77624

singhk@smh.ca

 

 

Dr Krishna Kumar Singh joined the group as a postdoctoral fellow in 2007 following Ph.D. studies in Human Genetics at Hannover Medical School, Germany where he was one of only 20 international students selected for the International MD/PhD program.  Dr Singh’s doctoral thesis focused on the different genes involved in Marfan syndrome, a genetic disease that includes aortic aneurysm as part of the condition along with other cardiovascular, skeletal and ocular system manifestations.  Since commencing postdoctoral research, Dr Singh has been awarded a Ministry of Research and Innovation Ontario Postdoctoral Fellowship, a Canadian Arthritis Network Postdoctoral Fellowship, a Heart and Stroke Foundation of Canada/Pfizer Research Fellowship and the prestigious 2009 Vivien Thomas Young Investigator Award from the American Heart Association.

 

 

Select publications:

 

Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S.

BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure.

J Biol Chem. 2012 Feb 24;287(9):6604-14

 

Yanagawa B, Lovren F, Pan Y, Garg V, Quan A, Tang G, Singh KK, Shukla PC, Kalra NP, Peterson MD, Verma S.

miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis.

J Thorac Cardiovasc Surg. 2012 Feb 13.

 

Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, Leong-Poi H, Al-Omran M, Verma S.

BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis.

Gene Ther. 2012 Jan 19. doi: 10.1038/gt.2011.214.

  

Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S.

BRCA1 is an essential regulator of heart function and survival following myocardial infarction.

Nat Commun. 2011 Dec 20;2:593.

 

Singh KK, Shukla PC, Quan A, Lovren F, Pan Y, Wolfstadt JI, Gupta M, Al-Omran M, Leong-Poi H, Teoh H, Verma S.

Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death.

Biochem Biophys Res Commun. 2011 Jul 29;411(2):421-6.

 

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, Al-Omran M, Teoh H, Verma S.

Adropin is a novel regulator of endothelial function

Circulation. 2010 Sep 14;122(11 Suppl):S185-92.

 

Singh KK, Krawczak M, Dawson WW, Schmidtke J
Association of HTRA1 and ARMS2 gene variation with drusen
formation in rhesus macaques.
Exp Eye Res. 2009 Mar;88(3):479-82. 

Singh KK, Shukla PC, Schmidtke J
Conservation of 5'-upstream region of the FBN1 gene in primates.
Eur J Hum Genet. 2008 Jul;16(7):869-72. 

Singh KK, Elligsen D, Liersch R, Schubert S, Pabst B,
Arslan-Kirchner M, Schmidtke J Multi-exon out of frame deletion of the FBN1 gene leading to a severe juvenile onset cardiovascular 
phenotype in Marfan syndrome.
J Mol Cell Cardiol. 2007 Feb;42(2):352-6. 

Singh KK, Dawson WW, Krawczak M, Schmidtke J
IMPG1 gene variation in rhesus macular drusen.
Vet Ophthalmol. 2007 Sep-Oct;10(5):274-7. 

Singh KK, Shukla PC, Rommel K, Schmidtke J, Arslan-Kirchner M
Sequence variations in the 5' upstream regions of the FBN1 
gene associated with Marfan syndrome.
Eur J Hum Genet. 2006 Jul;14(7):876-9. 

Singh KK, Rommel K, Mishra A, Karck M, Haverich A, Schmidtke J, Arslan-Kirchner M
TGFBR1 and TGFBR2 mutations in patients with features of 
Marfan syndrome and Loeys-Dietz syndrome.
Hum Mutat. 2006 Aug;27(8):770-7.

Singh KK, Schmidtke J
Single nucleotide polymorphisms within the promoter region of the rhesus monkey tumor necrosis factor-alpha gene.
Immunogenetics. 2005 May;57(3-4):289-92.

Singh KK, Ristau S, Dawson WW, Krawczak M, Schmidtke J
Mapping of a macular drusen susceptibility locus in rhesus 
macaques to the homologue of human chromosome 6q14-15.
Exp Eye Res. 2005 Oct;81(4):401-6.