VERMALAB

 

CARDIOMETABOLIC RESEARCH



 

Adrian Quan

 

Research Manager

MPhil

416-864-6060 x77457

quana@smh.ca

 

As the group's Research Manager, Adrian Quan oversees the day-to-day operation of Dr Verma's research group.  In addition to his research interests in the vascular and systemic impact of sepsis, Adrian manages various administrative aspects of the group's multi-disciplinary research and extensive collaborative network.  He has a BSc (Hons) in Cell and Molecular Biology from the University of Toronto, and an MPhil in Cardiovascular Pharmacology from the University of Hong Kong.  Through the course of his graduate degree and subsequent 10 years working at St Michael's Hospital, Adrian has developed expertise in techniques to measure functional assessment of large arteries, arterioles, and microvessels.

Select publications:

 

Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S.

BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure.

J Biol Chem. 2012 Feb 24;287(9):6604-14

 

Yanagawa B, Lovren F, Pan Y, Garg V, Quan A, Tang G, Singh KK, Shukla PC, Kalra NP, Peterson MD, Verma S.

miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis.

J Thorac Cardiovasc Surg. 2012 Feb 13.

 

Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, Leong-Poi H, Al-Omran M, Verma S.

BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis.

Gene Ther. 2012 Jan 19. doi: 10.1038/gt.2011.214.

  

Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S.

BRCA1 is an essential regulator of heart function and survival following myocardial infarction.

Nat Commun. 2011 Dec 20;2:593.

 

Singh KK, Shukla PC, Quan A, Lovren F, Pan Y, Wolfstadt JI, Gupta M, Al-Omran M, Leong-Poi H, Teoh H, Verma S.

Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death.

Biochem Biophys Res Commun. 2011 Jul 29;411(2):421-6.

 

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, Al-Omran M, Teoh H, Verma S.

Adropin is a novel regulator of endothelial function

Circulation. 2010 Sep 14;122(11 Suppl):S185-92.

 

Desjardins JF, Pourdjabbar A, Quan A, Leong-Poi H, Teichert-Kuliszewska K, Verma S, Parker TG.

Lack of S100A1 in mice confers a gender-dependent hypertensive phenotype and increased mortality after myocardial infarction.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1457-65.

 

Teoh H, Quan A, Leung SW, Man RY.

Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries.

Menopause. 2009 Jan-Feb;16(1):104-9.

 

Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S.

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1377-84.

 

Teoh H , Quan A, Bang KW, Wang G, Lovren F, Vu V, Haitsma JJ, Szmitko PE, Al-Omran M, Wang CH, Gupta M, Peterson MD, Zhang H, Chan L, Freedman J, Sweeney G, Verma S.

Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality.

Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E658-64.

 

Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, Szalai AJ, Ward ME, Verma S.

Impaired endothelial function in C-reactive protein overexpressing mice.

Atherosclerosis. 2008 Dec;201(2):318-25.

 

He JZ, Quan A, Xu Y, Teoh H, Wang G, Fish JE, Steer BM, Itohara S, Marsden PA, Davidge ST, Ward ME.

Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H684-93.

 

Quan A, Ward ME, Kulandavelu S, Adamson SL, Langille BL.

Endothelium-independent flow-induced dilation in the mouse carotid artery.

J Vasc Res. 2006;43(4):383-91.

 

Ward ME, Toporsian M, Scott JA, Teoh H, Govindaraju V, Quan A, Wener AD, Wang G, Bevan SC, Newton DC, Marsden PA.

Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant.

J Clin Invest. 2005 Nov;115(11):3128-39.